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6 min read     Created: July 28, 2023, 1 p.m.
Introduction:
Migraine headaches are a complex and debilitating neurological disorder that affects an estimated 1.3 billion people worldwide1. Characterized by recurrent moderate to severe headache attacks often accompanied by other symptoms, migraines can significantly impact an individual's quality of life. In this article, we will explore the multifaceted nature of migraines, including migraine triggers, and delve into the latest advancements in migraine management.
Understanding Migraine Headaches:
1. Epidemiology:
Migraine headaches affect 1 in 6 people. The total prevalence is 15.6% although females are twice more likely to be affected than males (20.7% vs 9.7%)2. Risk factors include having a strong family history, females of childbearing age, obesity, sleep disorders and medication (particularly anti-inflammatory) overuse3.
2. Pathophysiology:
Migraine headaches are a neurovascular disorder (affecting the nerves and blood vessels) and involve a combination of genetic4 and environmental factors. Abnormal nerve activity, particularly involving the trigeminal nerve (the main sensory nerve supplying the face), leads to the release of inflammatory substances, causing blood vessel dilation and nerve sensitization5,6. These processes trigger the pulsating pain and associated symptoms experienced during a migraine attack.
3. Types of Migraine:
Migraines can be categorized into several types7, with the two most common being:
a. Migraine without aura: This is the most common form and accounts for about 80% of cases, where the headache occurs without any preceding warning signs.
b. Migraine with aura: Approximately 20% of migraine sufferers experience this type, characterized by sensory disturbances or visual changes that precede the headache.
Symptoms and Triggers:
1. Typical Symptoms:
Migraine attacks are often described as throbbing or pounding headaches, usually affecting one side of the head (the word migraine originally comes from the Greek word hemi-krania literately meaning ‘half the head’ although 40% of patients do experience a bilateral headache). Headaches can last for up to 72hrs8,9. Other common symptoms include nausea, vomiting (in 20-30% of patients10), sensitivity to light (photophobia), and sensitivity to sound (phonophobia). Recognising the common symptoms of migraines is essential in identifying the most suitable treatment for migraine headaches, helping individuals better manage and cope with this condition.
2. Aura Symptoms:
For individuals experiencing migraine with aura, visual disturbances like flashes of light, visual sparkles, zigzag lines, or temporary vision loss may occur before the headache onset11. Visual disturbances are often described as being like the appearance of looking through a rain-covered window. Other aura symptoms may involve tingling or numbness in the face or extremities12. These aura symptoms not only serve as a warning sign of an impending migraine but also highlight the importance of early migraine treatment to mitigate the severity of the headache phase.
3. Triggers:
Identifying migraine triggers is a crucial step in effective migraine management. By understanding what triggers your migraines, you can take proactive measures to avoid them, thus reducing the frequency of attacks and the need for acute migraine treatment. Migraines can be triggered by various factors, including:
a. Certain foods and beverages (e.g., aged cheese, chocolate, caffeine, alcohol)
b. Stress and anxiety
c. Hormonal changes in women
d. Changes in sleep patterns
e. Environmental factors (e.g., bright lights, strong odours)
f. Weather changes
Management of Migraine Headaches:
1. Lifestyle Modifications:
a. Sleep: Encourage maintaining a regular sleep schedule and ensuring sufficient rest, as inadequate sleep can trigger migraines13.
b. Diet: Suggest keeping a migraine diary to identify and avoid potential trigger foods. Encourage a balanced diet and regular meal patterns14.
c. Stress Management: Techniques such as mindfulness, meditation, and relaxation exercises can help reduce stress and its impact on migraine frequency.
d. Physical Activity: Regular exercise can be beneficial in preventing migraines, but it's essential to avoid overexertion and to stay well-hydrated during physical activity15.
Incorporating these lifestyle changes not only serves as a preventive measure but also acts as a foundational treatment for migraine headaches by minimising potential triggers and promoting overall health.
2. Medications:
For those seeking ways on how to get rid of a migraine quickly, consulting a healthcare provider about these medications can make a significant difference in managing severe and recurring migraine attacks.
a. Acute Treatment: Migraine treatment needs to be started as soon as the headache is recognised – even if mild. Over-the-counter pain relievers (e.g., ibuprofen, aspirin, paracetamol, and combination analgesics containing caffeine) can be used during the early stages of a migraine attack16. Triptans (e.g., rizatriptan and sumatriptan) are migraine specific-prescription medications that can help constrict blood vessels and reduce inflammation, providing relief during the headache phase17. In Australia, these can be dispensed by pharmacists (without a prescription) for migraine headaches when simpler pain relief medicines are not effective. Because of their constricting effects on blood vessels, Triptans cannot be used in people with severe liver disease, heart disease, cerebrovascular disease and in pregnancy18. If nausea and vomiting are present ensuring adequate hydration and anti-nausea (anti-emetic) medications can be effective. Opioid pain relief medications should always be avoided because they are not as effective as other existing medications and carry a risk of long-term dependence19.
b. Preventive Treatment: For individuals with frequent and severe migraines, preventive medications may be prescribed to reduce the frequency and intensity of attacks. These include beta-blockers (e.g. propranolol), anticonvulsants (valproate, topiramate), antidepressants (amitriptyline). Calcitonin gene-related peptide (CGRP) inhibitors (galcanezumab and fremanezumab) are newer migraine preventative treatments and must be commenced by a specialist neurologist20.
c. Rescue Medications: In certain cases, a combination of acute and preventive medications may be used as "rescue" therapy when attacks are difficult to control.
Seeking Professional Help:
Migraines can significantly impact a person's life, and seeking medical attention is essential for proper diagnosis and management. A healthcare professional can perform a thorough evaluation, rule out other underlying conditions, and develop an individualized treatment plan.
For those whose migraine pain impacts their ability to work or attend school, obtaining a medical certificate can be an easy and convenient process through Medical Certificates Australia, ensuring you have the documentation you need when taking necessary time off due to severe migraines. We offer single or multiple-day medical certificates online, depending on your needs. In addition, if you are caring for a loved one with migraines, our carer’s leave medical certificates offer peace of mind and help you balance your work and caregiving duties.
Conclusion:
Migraine headaches are a complex neurological disorder that affects millions of individuals worldwide. Understanding the underlying pathophysiology, types of migraines, and common triggers is crucial in effectively managing this condition. Lifestyle modifications, stress management, and identifying trigger factors can help reduce the frequency and intensity of migraine attacks. Pharmacological treatments, including acute and preventive medications, play a vital role in providing relief and improving the overall quality of life for migraine sufferers.
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References:
1. GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018 Nov 10;392(10159):1789-858.
2. Burch R, Rizzoli P, Loder E. The prevalence and impact of migraine and severe headache in the United States: figures and trends from government health studies. Headache. 2018 Apr;58(4):496-505.
3. BMJ Publishing Group. Migraine Headache in Adults. BMJ best Practice. 2023. https://bestpractice.bmj.com [accessed 28/07/2023].
4. Sutherland HG, Griffiths LR. Genetics of migraine: insights into the molecular basis of migraine disorders. Headache. 2017 Apr;57(4):537-69.
5. Pietrobon D, Streissnig J. Neurobiology of migraine. Nat Rev. 2003 May;4(5):386-98.
6. Charles A. The pathophysiology of migraine: implications for clinical management. Lancet Neurol. 2018 Feb;17(2):174-82.
7. Headache Classification Committee of the International Headache Society (IHS). The international classification of headache disorders, 3rd edition. Cephalalgia. 2018 Jan;38(1):1-211.
8. Smetana GW. The diagnostic value of historical features in primary headache syndromes: a comprehensive review. Arch Intern Med. 2000 Oct 9;160(18):2729-37.
9. Sjaastad O, Fredriksen TA, Sand T, et al. Unilaterality of headache in classic migraine. Cephalalgia. 1989 Mar;9(1):71-7.
10. Silberstein SD, Saper JR, Freitag F. Migraine: diagnosis and treatment. In: Silberstein SD, Saper JR, Freitag F, eds. Wolff's headache and other head pain. 7th ed. New York, NY: Oxford University Press; 2001:128-30.
11. Detsky ME, McDonald DR, Baerlocher MO, et al. Does this patient with headache have a migraine or need neuroimaging? JAMA. 2006 Sep 13;296(10):1274-83.
12. Viana M, Tronvik EA, Do TP, et al. Clinical features of visual migraine aura: a systematic review. J Headache Pain. 2019 May 30;20(1):64.
13. Probyn K, Bowers H, Caldwell F, et al. Prognostic factors for chronic headache: a systematic review. Neurology. 2017 Jul;89(3): 291-301.
14. Martin VT, Vij B. Diet and headache: part 1. Headache. 2016 Oct;56(9):1543-52.
15. Amin FM, Aristeidou S, Baraldi C, et al. The association between migraine and physical exercise. J Headache Pain. 2018 Sep 10;19(1):83.
16. Rabbie RD, Derry S, Moore RA. Ibuprofen with or without an antiemetic for acute migraine headaches in adults. Cochrane Database Syst Rev. 2013 Apr 30;(4):CD008039.
17. Derry CJ, Derry S, Moore RA. Sumatriptan (oral route of administration) for acute migraine attacks in adults. Cochrane Database Syst Rev. 2012 Feb 15;(2):CD008615.
18. Australian Medicines Handbook Pty Ltd. Triptans. 2023 https://amhonline.amh.net.au [accessed 28/06/2023].
19. Orr SL, Friedman BW, Christie SC, et al. Management of adults with acute migraine in the emergency department: the American Headache Society evidence assessment of parenteral pharmacotherapies. Headache. 2016 Jun;56(6):911-40.
20. Australian Government Department of Health and Aged Care. The pharmaceutical benefits scheme. 2023. https://www.pbs.gov.au [accessed 28/07/2023].
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